A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

BACKGROUND: Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Recent studies have demonstrated functional interactions between chemokine and opio...

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Detalles Bibliográficos
Autores principales: Dutta, Raini, Lunzer, Mary M., Auger, Jennifer L., Akgün, Eyup, Portoghese, Philip S., Binstadt, Bryce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062996/
https://www.ncbi.nlm.nih.gov/pubmed/30053832
http://dx.doi.org/10.1186/s13075-018-1661-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062996/
https://www.ncbi.nlm.nih.gov/pubmed/30053832
http://dx.doi.org/10.1186/s13075-018-1661-5

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