ProTide generated long-acting abacavir nanoformulations

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

Detalles Bibliográficos
Autores principales: Lin, Zhiyi, Gautam, Nagsen, Alnouti, Yazen, McMillan, JoEllyn, Bade, Aditya N., Gendelman, Howard E., Edagwa, Benson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063073/
https://www.ncbi.nlm.nih.gov/pubmed/29995046
http://dx.doi.org/10.1039/c8cc04708a
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author Lin, Zhiyi
Gautam, Nagsen
Alnouti, Yazen
McMillan, JoEllyn
Bade, Aditya N.
Gendelman, Howard E.
Edagwa, Benson
author_facet Lin, Zhiyi
Gautam, Nagsen
Alnouti, Yazen
McMillan, JoEllyn
Bade, Aditya N.
Gendelman, Howard E.
Edagwa, Benson
author_sort Lin, Zhiyi
collection PubMed
description Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.
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spelling pubmed-60630732018-08-08 ProTide generated long-acting abacavir nanoformulations Lin, Zhiyi Gautam, Nagsen Alnouti, Yazen McMillan, JoEllyn Bade, Aditya N. Gendelman, Howard E. Edagwa, Benson Chem Commun (Camb) Chemistry Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days. Royal Society of Chemistry 2018-08-04 2018-07-11 /pmc/articles/PMC6063073/ /pubmed/29995046 http://dx.doi.org/10.1039/c8cc04708a Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Lin, Zhiyi
Gautam, Nagsen
Alnouti, Yazen
McMillan, JoEllyn
Bade, Aditya N.
Gendelman, Howard E.
Edagwa, Benson
ProTide generated long-acting abacavir nanoformulations
title ProTide generated long-acting abacavir nanoformulations
title_full ProTide generated long-acting abacavir nanoformulations
title_fullStr ProTide generated long-acting abacavir nanoformulations
title_full_unstemmed ProTide generated long-acting abacavir nanoformulations
title_short ProTide generated long-acting abacavir nanoformulations
title_sort protide generated long-acting abacavir nanoformulations
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063073/
https://www.ncbi.nlm.nih.gov/pubmed/29995046
http://dx.doi.org/10.1039/c8cc04708a
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AT badeadityan protidegeneratedlongactingabacavirnanoformulations
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