Analysis of Genetic Variation Indicates DNA Shape Involvement in Purifying Selection

Noncoding DNA sequences, which play various roles in gene expression and regulation, are under evolutionary pressure. Gene regulation requires specific protein–DNA binding events, and our previous studies showed that both DNA sequence and shape readout are employed by transcription factors (TFs) to...

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Detalles Bibliográficos
Autores principales: Wang, Xiaofei, Zhou, Tianyin, Wunderlich, Zeba, Maurano, Matthew T, DePace, Angela H, Nuzhdin, Sergey V, Rohs, Remo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063282/
https://www.ncbi.nlm.nih.gov/pubmed/29850830
http://dx.doi.org/10.1093/molbev/msy099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063282/
https://www.ncbi.nlm.nih.gov/pubmed/29850830
http://dx.doi.org/10.1093/molbev/msy099

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