Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid

BACKGROUND: To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and PET. Unfortunately, most of them suffer from metabolic instability, mainly hepatobiliary clearance and insufficient target binding. The intr...

Descripción completa

Detalles Bibliográficos
Autores principales: Hugenberg, Verena, Behrends, Malte, Wagner, Stefan, Hermann, Sven, Schäfers, Michael, Kolb, Hartmuth C., Szardenings, Katrin, Walsh, Joseph C., Gomez, Luis F., Kopka, Klaus, Haufe, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063323/
https://www.ncbi.nlm.nih.gov/pubmed/30101186
http://dx.doi.org/10.1186/s41181-018-0045-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063323/
https://www.ncbi.nlm.nih.gov/pubmed/30101186
http://dx.doi.org/10.1186/s41181-018-0045-0

Ejemplares similares