Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid

Overexpression of histone deacetylase (HDAC) isoforms has been implicated in a variety of disease pathologies, from cancer and colitis to cardiovascular disease and neurodegeneration, thus HDAC inhibitors have a long history as therapeutic targets. The gut microbiota can influence HDAC activity via...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuille, Samantha, Reichardt, Nicole, Panda, Suchita, Dunbar, Hayley, Mulder, Imke E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063406/
https://www.ncbi.nlm.nih.gov/pubmed/30052654
http://dx.doi.org/10.1371/journal.pone.0201073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063406/
https://www.ncbi.nlm.nih.gov/pubmed/30052654
http://dx.doi.org/10.1371/journal.pone.0201073

Ejemplares similares