Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae

Recombination and mutagenesis are elevated by active transcription. The correlation between transcription and genome instability is largely explained by the topological and structural changes in DNA and the associated physical obstacles generated by the transcription machinery. However, such explana...

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Detalles Bibliográficos
Autores principales: Owiti, Norah, Wei, Shanqiao, Bhagwat, Ashok S., Kim, Nayun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063437/
https://www.ncbi.nlm.nih.gov/pubmed/30016327
http://dx.doi.org/10.1371/journal.pgen.1007516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063437/
https://www.ncbi.nlm.nih.gov/pubmed/30016327
http://dx.doi.org/10.1371/journal.pgen.1007516

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