UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

Accumulating evidence indicates that the lysosomal Ragulator complex is essential for full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in several developmental neurological disorders, including Angelman syndrome (AS), which is...

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Detalles Bibliográficos
Autores principales: Sun, Jiandong, Liu, Yan, Jia, Yousheng, Hao, Xiaoning, Lin, Wei ju, Tran, Jennifer, Lynch, Gary, Baudry, Michel, Bi, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
https://www.ncbi.nlm.nih.gov/pubmed/30020076
http://dx.doi.org/10.7554/eLife.37993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
https://www.ncbi.nlm.nih.gov/pubmed/30020076
http://dx.doi.org/10.7554/eLife.37993

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