Cargando…

UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

Accumulating evidence indicates that the lysosomal Ragulator complex is essential for full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in several developmental neurological disorders, including Angelman syndrome (AS), which is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Jiandong, Liu, Yan, Jia, Yousheng, Hao, Xiaoning, Lin, Wei ju, Tran, Jennifer, Lynch, Gary, Baudry, Michel, Bi, Xiaoning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063731/ https://www.ncbi.nlm.nih.gov/pubmed/30020076 http://dx.doi.org/10.7554/eLife.37993

Ejemplares similares

Yin-and-Yang of mTORC1/C2 in Angelman syndrome mice
por: Bi, Xiaoning, et al.
Publicado: (2015)

LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
por: Sun, Jiandong, et al.
Publicado: (2022)

Novel neurobiological roles of UBE3A
por: Sun, Jiandong, et al.
Publicado: (2017)

Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome
por: Sun, Jiandong, et al.
Publicado: (2022)

PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome
por: Sun, Jiandong, et al.
Publicado: (2020)

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling
por: Liu, Ji-Ting, et al.
Publicado: (2021)

mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR
por: Sanders, Shaun S., et al.
Publicado: (2019)

A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release
por: Briz, Victor, et al.
Publicado: (2015)

RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
por: Li, Tingting, et al.
Publicado: (2021)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
por: Deng, Lu, et al.
Publicado: (2018)

LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinoma
por: Wu, Bo, et al.
Publicado: (2022)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase
por: Yoneyama, Yosuke, et al.
Publicado: (2018)

Role of Calpain-1 in Neurogenesis
por: Baudry, Michel, et al.
Publicado: (2021)

The impact of constitutive mTORC1 hyperactivity on structural synaptic plasticity and social behaviour under standard conditions and environmental enrichment
por: Granak, S., et al.
Publicado: (2022)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Regulation of filial imprinting and structural plasticity by mTORC1 in newborn chickens
por: Batista, Gervasio, et al.
Publicado: (2018)

Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice
por: Liu, Yan, et al.
Publicado: (2016)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A(2) Activity
por: Allyson, Julie, et al.
Publicado: (2012)

Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
por: Kaiser, Marco S., et al.
Publicado: (2022)

Regulation of TFEB and V-ATPases by mTORC1
por: Peña-Llopis, Samuel, et al.
Publicado: (2011)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells
por: Chen, Yu-Chuan, et al.
Publicado: (2020)

Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1
por: Roque, Patricia Soriano, et al.
Publicado: (2021)

Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation
por: Bialas, Johanna, et al.
Publicado: (2015)

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin
por: Huang, Yi, et al.
Publicado: (2018)

UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop
por: Liu, Xu, et al.
Publicado: (2020)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gvbal959so9qbbdhh4o9aliuvj