Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture and bacteriolysis preceding caspase-11 activation. We show he...

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Detalles Bibliográficos
Autores principales: Liu, Beiyun C., Sarhan, Joseph, Panda, Alexander, Muendlein, Hayley I., Ilyukha, Vladimir, Coers, Jörn, Yamamoto, Masahiro, Isberg, Ralph R., Poltorak, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063733/
https://www.ncbi.nlm.nih.gov/pubmed/29972777
http://dx.doi.org/10.1016/j.celrep.2018.06.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063733/
https://www.ncbi.nlm.nih.gov/pubmed/29972777
http://dx.doi.org/10.1016/j.celrep.2018.06.012

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