PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) were previously demonstrated in children, whereas chan...

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Detalles Bibliográficos
Autores principales: Emoto, Chie, Johnson, Trevor N., Neuhoff, Sibylle, Hahn, David, Vinks, Alexander A., Fukuda, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063742/
https://www.ncbi.nlm.nih.gov/pubmed/29920988
http://dx.doi.org/10.1002/psp4.12306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063742/
https://www.ncbi.nlm.nih.gov/pubmed/29920988
http://dx.doi.org/10.1002/psp4.12306

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