Study Design Selection in Early Clinical Anti‐Hyperglycemic Drug Development: A Simulation Study of Glucose Tolerance Tests

In antidiabetic drug development, phase I studies usually involve short‐term glucose provocations. Multiple designs are available for these provocations (e.g., meal tolerance tests (MTTs) and graded glucose infusions (GGIs)). With a highly nonlinear, complex system as the glucose homeostasis, the va...

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Detalles Bibliográficos
Autores principales: Ibrahim, Moustafa M. A., Ghadzi, Siti M. S., Kjellsson, Maria C., Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063744/
https://www.ncbi.nlm.nih.gov/pubmed/29732710
http://dx.doi.org/10.1002/psp4.12302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063744/
https://www.ncbi.nlm.nih.gov/pubmed/29732710
http://dx.doi.org/10.1002/psp4.12302

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