Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations cause atrophy of the optic nerve leading to blindness. Here, we show that OPA1 has an important role in the innate immune system....

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Detalles Bibliográficos
Autores principales: Amini, Poorya, Stojkov, Darko, Felser, Andrea, Jackson, Christopher B., Courage, Carolina, Schaller, André, Gelman, Laurent, Soriano, Maria Eugenia, Nuoffer, Jean-Marc, Scorrano, Luca, Benarafa, Charaf, Yousefi, Shida, Simon, Hans-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063938/
https://www.ncbi.nlm.nih.gov/pubmed/30054480
http://dx.doi.org/10.1038/s41467-018-05387-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063938/
https://www.ncbi.nlm.nih.gov/pubmed/30054480
http://dx.doi.org/10.1038/s41467-018-05387-y

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