Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts

Pirfenidone is a representative medication to treat interstitial pulmonary fibrosis. Researchers reported pirfenidone (>100 µg/ml) significantly suppressed fibroblast growth in vitro. However, clinically, the maximum concentration of pirfenidone in the blood is approximately 10 µg/ml. We hypothes...

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Detalles Bibliográficos
Autores principales: Toda, Michihito, Mizuguchi, Shinjiro, Minamiyama, Yukiko, Yamamoto-Oka, Hiroko, Aota, Takanori, Kubo, Shoji, Nishiyama, Noritoshi, Shibata, Toshihiko, Takemura, Shigekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064814/
https://www.ncbi.nlm.nih.gov/pubmed/30087545
http://dx.doi.org/10.3164/jcbn.17-111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064814/
https://www.ncbi.nlm.nih.gov/pubmed/30087545
http://dx.doi.org/10.3164/jcbn.17-111

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