Nephron‐Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion

BACKGROUND: In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na(+) transport. METHODS AND RESULTS: To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline‐inducible nephron‐wide deletion of NOS3 were generated. During 1 week of salt loading,...

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Detalles Bibliográficos
Autores principales: Gao, Yang, Stuart, Deborah, Takahishi, Takamune, Kohan, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064857/
https://www.ncbi.nlm.nih.gov/pubmed/29997131
http://dx.doi.org/10.1161/JAHA.118.009236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064857/
https://www.ncbi.nlm.nih.gov/pubmed/29997131
http://dx.doi.org/10.1161/JAHA.118.009236

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