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Nephron‐Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion

BACKGROUND: In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na(+) transport. METHODS AND RESULTS: To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline‐inducible nephron‐wide deletion of NOS3 were generated. During 1 week of salt loading,...

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Detalles Bibliográficos
Autores principales:	Gao, Yang, Stuart, Deborah, Takahishi, Takamune, Kohan, Donald E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064857/ https://www.ncbi.nlm.nih.gov/pubmed/29997131 http://dx.doi.org/10.1161/JAHA.118.009236

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