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Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

BACKGROUND: Although estrogen receptor α (ERα) acts primarily as a transcription factor, it can also elicit membrane‐initiated steroid signaling. Pharmacological tools and transgenic mouse models previously highlighted the key role of ERα membrane‐initiated steroid signaling in 2 actions of estrogen...

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Detalles Bibliográficos
Autores principales: Guivarc'h, Emmanuel, Buscato, Mélissa, Guihot, Anne‐Laure, Favre, Julie, Vessières, Emilie, Grimaud, Linda, Wakim, Jamal, Melhem, Nada‐Joe, Zahreddine, Rana, Adlanmerini, Marine, Loufrani, Laurent, Knauf, Claude, Katzenellenbogen, John A., Katzenellenbogen, Benita S., Foidart, Jean‐Michel, Gourdy, Pierre, Lenfant, Françoise, Arnal, Jean‐François, Henrion, Daniel, Fontaine, Coralie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064913/
https://www.ncbi.nlm.nih.gov/pubmed/29959137
http://dx.doi.org/10.1161/JAHA.118.008950