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Positional specificity of different transcription factor classes within enhancers

Gene expression is controlled by sequence-specific transcription factors (TFs), which bind to regulatory sequences in DNA. TF binding occurs in nucleosome-depleted regions of DNA (NDRs), which generally encompass regions with lengths similar to those protected by nucleosomes. However, less is known...

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Detalles Bibliográficos
Autores principales: Grossman, Sharon R., Engreitz, Jesse, Ray, John P., Nguyen, Tung H., Hacohen, Nir, Lander, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065035/
https://www.ncbi.nlm.nih.gov/pubmed/29987030
http://dx.doi.org/10.1073/pnas.1804663115