Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis

BACKGROUND: The transcription factor NF-kB plays an important role in the pathogenesis of rheumatoid arthritis (RA). Effective treatment of RA is hindered due to the lack of specificity of small molecules in the inflamed joints. In this study, we aimed to develop a unique hybrid-nanoparticles system...

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Detalles Bibliográficos
Autores principales: Duan, Weifeng, Li, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065064/
https://www.ncbi.nlm.nih.gov/pubmed/30060740
http://dx.doi.org/10.1186/s12951-018-0382-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065064/
https://www.ncbi.nlm.nih.gov/pubmed/30060740
http://dx.doi.org/10.1186/s12951-018-0382-x

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