An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules

Microtubule-based molecular motors mediate transport of intracellular cargo to subdomains in neurons. Previous evidence has suggested that the anesthetic propofol decreases the average run-length potential of the major anterograde transporters kinesin-1 and kinesin-2 without altering their velocity....

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Detalles Bibliográficos
Autores principales: Woll, Kellie A., Guzik-Lendrum, Stephanie, Bensel, Brandon M., Bhanu, Natarajan V., Dailey, William P., Garcia, Benjamin A., Gilbert, Susan P., Eckenhoff, Roderic G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065180/
https://www.ncbi.nlm.nih.gov/pubmed/29844014
http://dx.doi.org/10.1074/jbc.RA118.002182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065180/
https://www.ncbi.nlm.nih.gov/pubmed/29844014
http://dx.doi.org/10.1074/jbc.RA118.002182

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