Cargando…
An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules
Microtubule-based molecular motors mediate transport of intracellular cargo to subdomains in neurons. Previous evidence has suggested that the anesthetic propofol decreases the average run-length potential of the major anterograde transporters kinesin-1 and kinesin-2 without altering their velocity....
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065180/ https://www.ncbi.nlm.nih.gov/pubmed/29844014 http://dx.doi.org/10.1074/jbc.RA118.002182 |