T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

Activation of the β(2) integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element (ARE)-bearing mRNAs, by triggering the nuclear-to-cytoplasmic translocation of the mRNA-binding and -stabilizing protein HuR. However, the mechanism by...

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Detalles Bibliográficos
Autores principales: Rao, Gautham K., Wong, Albert, Collinge, Mark, Sarhan, Joseph, Yarovinsky, Timur O., Ramgolam, Vinod S., Gaestel, Matthias, Pardi, Ruggero, Bender, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065199/
https://www.ncbi.nlm.nih.gov/pubmed/30048492
http://dx.doi.org/10.1371/journal.pone.0201103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065199/
https://www.ncbi.nlm.nih.gov/pubmed/30048492
http://dx.doi.org/10.1371/journal.pone.0201103

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