Structural insights into SorCS2–Nerve Growth Factor complex formation

Signaling of SorCS receptors by proneurotrophin ligands regulates neuronal plasticity, induces apoptosis and is associated with mental disorders. The detailed structure of SorCS2 and its extracellular specificity are unresolved. Here we report crystal structures of the SorCS2–NGF complex and unligan...

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Detalles Bibliográficos
Autores principales: Leloup, Nadia, Chataigner, Lucas M. P., Janssen, Bert J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065357/
https://www.ncbi.nlm.nih.gov/pubmed/30061605
http://dx.doi.org/10.1038/s41467-018-05405-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065357/
https://www.ncbi.nlm.nih.gov/pubmed/30061605
http://dx.doi.org/10.1038/s41467-018-05405-z

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