Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1(G93A) ALS mouse model

Amyotrophic lateral sclerosis (ALS) is an untreatable, progressive, neurodegenerative disease specifically affecting motor neurons. Recently, the tyrosine kinase receptor EphA4 was directly implicated in ALS disease progression. We report that a long-lived mutated form of the EphA4 antagonist EphA4-...

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Detalles Bibliográficos
Autores principales: Zhao, J., Cooper, L. T., Boyd, A. W., Bartlett, P. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065374/
https://www.ncbi.nlm.nih.gov/pubmed/30061574
http://dx.doi.org/10.1038/s41598-018-29845-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065374/
https://www.ncbi.nlm.nih.gov/pubmed/30061574
http://dx.doi.org/10.1038/s41598-018-29845-1

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