Improved phosphoproteomic analysis for phosphosignaling and active-kinome profiling in Matrigel-embedded spheroids and patient-derived organoids

Many attempts have been made to reproduce the three-dimensional (3D) cancer behavior. For that purpose, Matrigel, an extracellular matrix from Engelbreth-Holm-Swarm mouse sarcoma cell, is widely used in 3D cancer models such as scaffold-based spheroids and patient-derived organoids. However, severe...

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Detalles Bibliográficos
Autores principales: Abe, Yuichi, Tada, Asa, Isoyama, Junko, Nagayama, Satoshi, Yao, Ryoji, Adachi, Jun, Tomonaga, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065387/
https://www.ncbi.nlm.nih.gov/pubmed/30061712
http://dx.doi.org/10.1038/s41598-018-29837-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065387/
https://www.ncbi.nlm.nih.gov/pubmed/30061712
http://dx.doi.org/10.1038/s41598-018-29837-1

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