Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power

Mutant allele frequency distributions in cancer samples have been used to estimate intratumoral heterogeneity and its implications for patient survival. However, mutation calls are sensitive to the calling algorithm. It remains unknown whether the relationship of heterogeneity and clinical outcome i...

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Detalles Bibliográficos
Autores principales: Noorbakhsh, Javad, Kim, Hyunsoo, Namburi, Sandeep, Chuang, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065409/
https://www.ncbi.nlm.nih.gov/pubmed/30061557
http://dx.doi.org/10.1038/s41598-018-29154-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065409/
https://www.ncbi.nlm.nih.gov/pubmed/30061557
http://dx.doi.org/10.1038/s41598-018-29154-7

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