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Distribution-based measures of tumor heterogeneity are sensitive to mutation calling and lack strong clinical predictive power
Mutant allele frequency distributions in cancer samples have been used to estimate intratumoral heterogeneity and its implications for patient survival. However, mutation calls are sensitive to the calling algorithm. It remains unknown whether the relationship of heterogeneity and clinical outcome i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065409/ https://www.ncbi.nlm.nih.gov/pubmed/30061557 http://dx.doi.org/10.1038/s41598-018-29154-7 |