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Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues

Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell proliferation and cell adhesion, yet their mutations are often confined to specific cancer types. To resolve this paradox, we explained mutation frequencies of selected genes across tumor types with four fea...

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Detalles Bibliográficos
Autores principales: Tiong, Khong-Loon, Yeang, Chen-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065413/
https://www.ncbi.nlm.nih.gov/pubmed/30061703
http://dx.doi.org/10.1038/s41598-018-29861-1