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Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis
We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065815/ https://www.ncbi.nlm.nih.gov/pubmed/30043857 http://dx.doi.org/10.1590/1414-431X20187560 |