Design of a Novel Gene Therapy Construct to Achieve Sustained Brain-Derived Neurotrophic Factor Signaling in Neurons

Brain-derived neurotrophic factor (BDNF) acting through the tropomyosin-related receptor-B (TrkB) is an important signaling system for the maintenance and survival of neurons. Gene therapy using either recombinant adeno-associated virus (AAV) or lentiviral vectors can provide sustained delivery of B...

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Detalles Bibliográficos
Autores principales: Osborne, Andrew, Wang, Aiden X.Z., Tassoni, Alessia, Widdowson, Peter S., Martin, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066195/
https://www.ncbi.nlm.nih.gov/pubmed/29466871
http://dx.doi.org/10.1089/hum.2017.069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066195/
https://www.ncbi.nlm.nih.gov/pubmed/29466871
http://dx.doi.org/10.1089/hum.2017.069

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