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Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
BACKGROUND: Chromatin loops form a basic unit of interphase nuclear organization, with chromatin loop anchor points providing contacts between regulatory regions and promoters. However, the mutational landscape at these anchor points remains under-studied. Here, we describe the unusual patterns of s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066925/ https://www.ncbi.nlm.nih.gov/pubmed/30060743 http://dx.doi.org/10.1186/s13059-018-1483-4 |