Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis

The spread of multidrug-resistant isolates of Mycobacterium tuberculosis requires the discovery of new drugs directed to new targets. In this study, we investigated the activity of two boldine-derived alkaloids, seconeolitsine (SCN) and N-methyl-seconeolitsine (N-SCN), against M. tuberculosis. These...

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Detalles Bibliográficos
Autores principales: García, María T., Carreño, David, Tirado-Vélez, José M., Ferrándiz, María J., Rodrigues, Liliana, Gracia, Begoña, Amblar, Mónica, Ainsa, José A., de la Campa, Adela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066988/
https://www.ncbi.nlm.nih.gov/pubmed/30087665
http://dx.doi.org/10.3389/fmicb.2018.01659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066988/
https://www.ncbi.nlm.nih.gov/pubmed/30087665
http://dx.doi.org/10.3389/fmicb.2018.01659

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