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Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis

The spread of multidrug-resistant isolates of Mycobacterium tuberculosis requires the discovery of new drugs directed to new targets. In this study, we investigated the activity of two boldine-derived alkaloids, seconeolitsine (SCN) and N-methyl-seconeolitsine (N-SCN), against M. tuberculosis. These...

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Detalles Bibliográficos
Autores principales:	García, María T., Carreño, David, Tirado-Vélez, José M., Ferrándiz, María J., Rodrigues, Liliana, Gracia, Begoña, Amblar, Mónica, Ainsa, José A., de la Campa, Adela G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066988/ https://www.ncbi.nlm.nih.gov/pubmed/30087665 http://dx.doi.org/10.3389/fmicb.2018.01659

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