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Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease

Clinical application of stem cell derivatives requires clinical-grade cells and sufficient preclinical proof of safety and efficacy, preferably in primates. We previously successfully established a clinical-grade human parthenogenetic embryonic stem cell (hPESC) line, but the suitability of its subt...

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Detalles Bibliográficos
Autores principales: Wang, Yu-Kai, Zhu, Wan-Wan, Wu, Meng-Hua, Wu, Yi-Hui, Liu, Zheng-Xin, Liang, Ling-Min, Sheng, Chao, Hao, Jie, Wang, Liu, Li, Wei, Zhou, Qi, Hu, Bao-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067059/
https://www.ncbi.nlm.nih.gov/pubmed/29910127
http://dx.doi.org/10.1016/j.stemcr.2018.05.010