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Suppression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function in Thalamocortical Neurons Prevents Genetically Determined and Pharmacologically Induced Absence Seizures

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and the I(h) current they generate contribute to the pathophysiological mechanisms of absence seizures (ASs), but their precise role in neocortical and thalamic neuronal populations, the main components of the network underlying AS g...

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Detalles Bibliográficos
Autores principales: David, François, Çarçak, Nihan, Furdan, Szabina, Onat, Filiz, Gould, Timothy, Mészáros, Ádám, Di Giovanni, Giuseppe, Hernández, Vivian M., Chan, C. Savio, Lőrincz, Magor L., Crunelli, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067077/
https://www.ncbi.nlm.nih.gov/pubmed/29925625
http://dx.doi.org/10.1523/JNEUROSCI.0896-17.2018