Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)...

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Detalles Bibliográficos
Autores principales: Ashmore, Joseph H, Luo, Shaman, Watson, Christy J W, Lazarus, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Carcinogenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067128/
https://www.ncbi.nlm.nih.gov/pubmed/29788210
http://dx.doi.org/10.1093/carcin/bgy065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067128/
https://www.ncbi.nlm.nih.gov/pubmed/29788210
http://dx.doi.org/10.1093/carcin/bgy065

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