Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

Ageing of haematopoietic stem cells (HSC) contributes to deficits in the aged haematopoietic system. HSC decline is driven in part by DNA damage accumulation, yet how aging impacts the acute DNA damage response (DDR) of HSCs is poorly understood. We show that old HSCs exhibit diminished ATM activity...

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Detalles Bibliográficos
Autores principales: Gutierrez-Martinez, Paula, Hogdal, Leah, Nagai, Manavi, Kruta, Miriama, Singh, Rumani, Sarosiek, Kristopher, Nussenzweig, Andre, Beerman, Isabel, Letai, Anthony, Rossi, Derrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067675/
https://www.ncbi.nlm.nih.gov/pubmed/29531308
http://dx.doi.org/10.1038/s41556-018-0054-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067675/
https://www.ncbi.nlm.nih.gov/pubmed/29531308
http://dx.doi.org/10.1038/s41556-018-0054-y

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