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Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay

[Image: see text] Solute carriers (SLCs) are transmembrane proteins that transport various nutrients, metabolites, and drugs across cellular membranes. Despite the relevance of SLCs to cell homeostasis, metabolism, and disease states, for the majority of SLCs we lack experimental evidence regarding...

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Detalles Bibliográficos
Autores principales: Hashimoto, Mari, Girardi, Enrico, Eichner, Ruth, Superti-Furga, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067815/
https://www.ncbi.nlm.nih.gov/pubmed/29851333
http://dx.doi.org/10.1021/acschembio.8b00270