Aggregates of IVIG or Avastin, but not HSA, modify the response to model innate immune response modulating impurities

Therapeutic proteins can induce immune responses that affect their safety and efficacy. Product aggregates and innate immune response modulating impurities (IIRMI) are risk factors of product immunogenicity. In this study, we use Intravenous Immunoglobulin (IVIG), Avastin, and Human Serum Albumin (H...

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Detalles Bibliográficos
Autores principales: Polumuri, Swamy Kumar, Haile, Lydia A., Ireland, Derek D. C., Verthelyi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068171/
https://www.ncbi.nlm.nih.gov/pubmed/30065306
http://dx.doi.org/10.1038/s41598-018-29850-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068171/
https://www.ncbi.nlm.nih.gov/pubmed/30065306
http://dx.doi.org/10.1038/s41598-018-29850-4

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