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Aggregates of IVIG or Avastin, but not HSA, modify the response to model innate immune response modulating impurities
Therapeutic proteins can induce immune responses that affect their safety and efficacy. Product aggregates and innate immune response modulating impurities (IIRMI) are risk factors of product immunogenicity. In this study, we use Intravenous Immunoglobulin (IVIG), Avastin, and Human Serum Albumin (H...
Autores principales: | Polumuri, Swamy Kumar, Haile, Lydia A., Ireland, Derek D. C., Verthelyi, Daniela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068171/ https://www.ncbi.nlm.nih.gov/pubmed/30065306 http://dx.doi.org/10.1038/s41598-018-29850-4 |
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