Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes

A simple protocol to overcome the problematic trifluoromethylation of carbonyl compounds by the potent greenhouse gas “HFC-23, fluoroform” with a potassium base is described. Simply the use of glymes as a solvent or an additive dramatically improves the yields of this transformation. Experimental re...

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Detalles Bibliográficos
Autores principales: Saito, Takuya, Wang, Jiandong, Tokunaga, Etsuko, Tsuzuki, Seiji, Shibata, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068191/
https://www.ncbi.nlm.nih.gov/pubmed/30065282
http://dx.doi.org/10.1038/s41598-018-29748-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068191/
https://www.ncbi.nlm.nih.gov/pubmed/30065282
http://dx.doi.org/10.1038/s41598-018-29748-1

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