Silencing of adaptor protein SH3BP2 reduces KIT/PDGFRA receptors expression and impairs gastrointestinal stromal tumors growth

Gastrointestinal stromal tumors (GISTs) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most GISTs contain oncogenic KIT (85%) or PDGFRA (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatment for these tumors; however, the development of...

Descripción completa

Detalles Bibliográficos
Autores principales: Serrano‐Candelas, Eva, Ainsua‐Enrich, Erola, Navinés‐Ferrer, Arnau, Rodrigues, Paulo, García‐Valverde, Alfonso, Bazzocco, Sarah, Macaya, Irati, Arribas, Joaquín, Serrano, César, Sayós, Joan, Arango, Diego, Martin, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068349/
https://www.ncbi.nlm.nih.gov/pubmed/29885053
http://dx.doi.org/10.1002/1878-0261.12332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068349/
https://www.ncbi.nlm.nih.gov/pubmed/29885053
http://dx.doi.org/10.1002/1878-0261.12332

Ejemplares similares