MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B

The heavily transcribed rDNA repeats that give rise to the ribosomal RNA are clustered in a unique chromatin structure, the nucleolus. Due to its highly repetitive nature and transcriptional activity, the nucleolus is considered a hotspot of genomic instability. Breaks in rDNA induce a transient tra...

Descripción completa

Detalles Bibliográficos
Autores principales: Pefani, Dafni Eleftheria, Tognoli, Maria Laura, Pirincci Ercan, Deniz, Gorgoulis, Vassilis, O'Neill, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068430/
https://www.ncbi.nlm.nih.gov/pubmed/29789391
http://dx.doi.org/10.15252/embj.201798760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068430/
https://www.ncbi.nlm.nih.gov/pubmed/29789391
http://dx.doi.org/10.15252/embj.201798760

Ejemplares similares