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Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission
Aged proteins can become hazardous to cellular function, by accumulating molecular damage. This implies that cells should preferentially rely on newly produced ones. We tested this hypothesis in cultured hippocampal neurons, focusing on synaptic transmission. We found that newly synthesized vesicle...
Autores principales: | Truckenbrodt, Sven, Viplav, Abhiyan, Jähne, Sebastian, Vogts, Angela, Denker, Annette, Wildhagen, Hanna, Fornasiero, Eugenio F, Rizzoli, Silvio O |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068464/ https://www.ncbi.nlm.nih.gov/pubmed/29950309 http://dx.doi.org/10.15252/embj.201798044 |
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