Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation

AIM: To overcome the hazardous effects on liver caused by long-term use of antitubercular agent isoniazid (INH) by developing a novel hepatoprotective prodrug strategy by conjugating INH with aminothiols as antioxidant promoities for probable synergistic effect. METHODS: INH was conjugated with N-ac...

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Detalles Bibliográficos
Autores principales: Bhilare, Neha Vithal, Dhaneshwar, Suneela Sunil, Mahadik, Kakasaheb Ramoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068850/
https://www.ncbi.nlm.nih.gov/pubmed/30079136
http://dx.doi.org/10.4254/wjh.v10.i7.496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068850/
https://www.ncbi.nlm.nih.gov/pubmed/30079136
http://dx.doi.org/10.4254/wjh.v10.i7.496

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