Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

CD4(+) T regulatory (T(reg)) cells are central to immune homeostasis, their phenotypic heterogeneity reflecting the diverse environments and target cells they regulate. To understand this heterogeneity, we combined single-cell RNAseq, activation reporter and TCR analysis to profile thousands of T(re...

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Detalles Bibliográficos
Autores principales: Zemmour, David, Zilionis, Rapolas, Kiner, Evgeny, Klein, Allon M, Mathis, Diane, Benoist, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069633/
https://www.ncbi.nlm.nih.gov/pubmed/29434354
http://dx.doi.org/10.1038/s41590-018-0051-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069633/
https://www.ncbi.nlm.nih.gov/pubmed/29434354
http://dx.doi.org/10.1038/s41590-018-0051-0

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