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Dysregulation of NF-kB in glandular epithelial cells results in Sjögren’s-like features

The autoimmune disease primary Sjögren’s syndrome (pSS) is characterized by hypofunction of the salivary glands (SGs), the cause of which is not correlated to lymphocytic SG infiltration, as prevailing dogma often states. We knocked out the NF-κB proinflammatory pathway inhibitor A20 in keratin14(+)...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoyan, Shaalan, Abeer, Liefers, Silvia, Coudenys, Julie, Elewaut, Dirk, Proctor, Gordon B., Bootsma, Hendrika, Kroese, Frans G. M., Pringle, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070175/
https://www.ncbi.nlm.nih.gov/pubmed/30067782
http://dx.doi.org/10.1371/journal.pone.0200212