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Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons

Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini. Virus particles must undergo long distance retrograde axonal transport to reach the neuron cell bodies in the peripheral or cen...

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Detalles Bibliográficos
Autores principales: MacGibeny, Margaret A., Koyuncu, Orkide O., Wirblich, Christoph, Schnell, Matthias J., Enquist, Lynn W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070286/
https://www.ncbi.nlm.nih.gov/pubmed/30028873
http://dx.doi.org/10.1371/journal.ppat.1007188