Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

BACKGROUND: Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations exceed therapeutic levels. Metformin-induced lactic acidosis has been linked t...

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Detalles Bibliográficos
Autores principales: Piel, Sarah, Ehinger, Johannes K., Chamkha, Imen, Frostner, Eleonor Åsander, Sjövall, Fredrik, Elmér, Eskil, Hansson, Magnus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070446/
https://www.ncbi.nlm.nih.gov/pubmed/30069806
http://dx.doi.org/10.1186/s40635-018-0186-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070446/
https://www.ncbi.nlm.nih.gov/pubmed/30069806
http://dx.doi.org/10.1186/s40635-018-0186-1

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