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Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production
BACKGROUND: Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of lactic acidosis under circumstances where plasma concentrations exceed therapeutic levels. Metformin-induced lactic acidosis has been linked t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070446/ https://www.ncbi.nlm.nih.gov/pubmed/30069806 http://dx.doi.org/10.1186/s40635-018-0186-1 |