Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis

Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are currently incurable due to primary or secondary resistance to glucocorticoid-based therapies. Here we employed an integrated approach to selectively kill T-ALL cells by increasing mitochondrial reactive oxygen sp...

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Detalles Bibliográficos
Autores principales: Silic-Benussi, Micol, Scattolin, Gloria, Cavallari, Ilaria, Minuzzo, Sonia, del Bianco, Paola, Francescato, Samuela, Basso, Giuseppe, Indraccolo, Stefano, D’Agostino, Donna M., Ciminale, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070521/
https://www.ncbi.nlm.nih.gov/pubmed/30069011
http://dx.doi.org/10.1038/s41419-018-0870-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070521/
https://www.ncbi.nlm.nih.gov/pubmed/30069011
http://dx.doi.org/10.1038/s41419-018-0870-9

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